Robert D Simari Selected Research

lipoprotein-associated coagulation inhibitor (TFPI)

1/2021	The contribution of TFPIα to the hemostatic response to injury in mice.
2/2015	Chronic passive venous congestion drives hepatic fibrogenesis via sinusoidal thrombosis and mechanical forces.
3/2012	Tissue factor pathway inhibitor blocks angiogenesis via its carboxyl terminus.
1/2012	Tissue factor pathway inhibitor as a multifunctional mediator of vascular structure.
9/2010	Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis.
7/2010	Tissue factor pathway inhibitor overexpression inhibits hypoxia-induced pulmonary hypertension.
1/2010	Murine strain differences in hemostasis and thrombosis and tissue factor pathway inhibitor.
9/2009	Vascular-directed tissue factor pathway inhibitor overexpression regulates plasma cholesterol and reduces atherosclerotic plaque development.
9/2004	The effect of vascular smooth muscle cell-targeted expression of tissue factor pathway inhibitor in a murine model of arterial thrombosis.
4/2003	Tissue factor pathway inhibitor deficiency enhances neointimal proliferation and formation in a murine model of vascular remodelling.

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Robert D Simari Research Topics

Disease

15	Myocardial Infarction 01/2018 - 07/2007
11	Heart Failure 11/2020 - 05/2004
9	Cardiovascular Diseases (Cardiovascular Disease) 08/2021 - 03/2002
8	Thrombosis (Thrombus) 01/2021 - 09/2004
8	Coronary Artery Disease (Coronary Atherosclerosis) 01/2018 - 04/2007
7	Left Ventricular Dysfunction 10/2014 - 07/2007
6	Vascular Diseases (Vascular Disease) 04/2015 - 09/2004
5	Fibrosis (Cirrhosis) 01/2018 - 07/2010
4	Vascular System Injuries 01/2021 - 12/2006
4	Cardiomyopathies (Cardiomyopathy) 11/2020 - 01/2016
4	Hypertension (High Blood Pressure) 01/2019 - 04/2010
4	Myocardial Ischemia (Ischemic Heart Diseases) 01/2015 - 01/2008
4	Atherosclerosis 12/2012 - 09/2003
3	Cicatrix (Scar) 01/2021 - 07/2007
3	Wounds and Injuries (Trauma) 01/2021 - 03/2005
3	Hemorrhage 01/2021 - 01/2010
3	ST Elevation Myocardial Infarction 01/2018 - 12/2012
3	Infarction (Infarctions) 01/2015 - 03/2006
3	Atherosclerotic Plaque (Atheroma) 07/2014 - 06/2007
3	Inflammation (Inflammations) 05/2013 - 07/2010
3	Ischemia 03/2012 - 03/2009
3	Vascular Remodeling 01/2012 - 04/2003
3	Neointima 02/2011 - 04/2003
2	Heart Diseases (Heart Disease) 02/2016 - 07/2010
2	Vascular Calcification 12/2012 - 12/2012
2	Hypertrophy 07/2010 - 05/2004
1	Intermittent Claudication 04/2017
1	Stroke (Strokes) 04/2017
1	Peripheral Arterial Disease 04/2017
1	Infections 02/2016
1	Endocarditis 02/2016
1	Diabetes Mellitus 04/2014
1	Renal Artery Obstruction (Renal Artery Stenosis) 04/2013
1	Atrophy 04/2013
1	Body Weight (Weight, Body) 05/2012
1	Chronic Limb-Threatening Ischemia 05/2012
1	Melanoma (Melanoma, Malignant) 01/2012
1	Hypoxia (Hypoxemia) 07/2010
1	Pulmonary Hypertension 07/2010
1	Atrial Fibrillation 04/2010
1	Ventricular Remodeling 01/2010

Drug/Important Bio-Agent (IBA)

10	lipoprotein-associated coagulation inhibitor (TFPI)IBA 01/2021 - 04/2003
4	Biomarkers (Surrogate Marker)IBA 08/2021 - 10/2014
3	FibrinIBA 01/2021 - 07/2010
3	Hemostatics (Antihemorrhagics)IBA 01/2021 - 09/2004
3	OsteocalcinIBA 02/2015 - 12/2012
3	Apolipoproteins E (ApoE)IBA 07/2014 - 06/2007
3	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2013 - 08/2004
2	omega-Chloroacetophenone (Mace)IBA 01/2021 - 01/2018
2	AnthracyclinesIBA 11/2020 - 01/2018
2	salicylhydroxamic acid (SHAM)IBA 05/2012 - 07/2010
2	ferric chlorideIBA 09/2010 - 09/2004
2	Acetates (Acetic Acid Esters)FDA Link 09/2010 - 07/2010
2	Desoxycorticosterone (Deoxycorticosterone)IBA 09/2010 - 07/2010
2	Thromboplastin (Tissue Factor)IBA 07/2010 - 01/2010
2	ApolipoproteinsIBA 09/2009 - 06/2007
2	Pregnancy-Associated Plasma Protein-A (PAPP-A)IBA 06/2007 - 12/2006
2	Metalloproteases (Metalloproteinases)IBA 06/2007 - 12/2006
2	Insulin-Like Growth Factor I (IGF-1)IBA 06/2007 - 12/2006
2	Phenobarbital (Luminal)FDA Link 10/2004 - 04/2003
1	Thrombin FDA Link 01/2021
1	pro-brain natriuretic peptide (1-76)IBA 01/2018
1	Aldehyde DehydrogenaseIBA 04/2017
1	Coloring Agents (Dyes)IBA 02/2016
1	Hematoxylin (Haematoxylon)IBA 02/2016
1	Eosine Yellowish-(YS) (Eosin)IBA 02/2016
1	C-Reactive ProteinIBA 01/2016
1	Alkaline PhosphataseIBA 02/2015
1	Warfarin (Coumadin)FDA LinkGeneric 02/2015
1	oxidized low density lipoproteinIBA 07/2014
1	SB 203580IBA 04/2013
1	p38 Mitogen-Activated Protein KinasesIBA 04/2013
1	Vascular Endothelial Growth Factor CIBA 01/2012
1	MorpholinosIBA 01/2012
1	Desoxycorticosterone Acetate (DOCA)FDA Link 09/2010
1	Hydroxysteroid DehydrogenasesIBA 07/2010
1	OsteopontinIBA 07/2010
1	MineralocorticoidsIBA 07/2010
1	SaltsIBA 07/2010
1	Mineralocorticoid Receptors (Mineralocorticoid Receptor)IBA 07/2010
1	2'- deoxythymidylyl- (3'- 5')- 2'- deoxyadenosine (d(AT))IBA 07/2010
1	CreatinineIBA 04/2010
1	CholesterolIBA 09/2009
1	ReninIBA 07/2009
1	Peptides (Polypeptides)IBA 07/2009
1	AngiotensinsIBA 07/2009
1	acetyl-LDLIBA 05/2009
1	Insulin-Like PeptidesIBA 06/2007

Therapy/Procedure

19	Therapeutics 01/2018 - 03/2002
17	Cell- and Tissue-Based Therapy (Cell Therapy) 11/2020 - 07/2007
5	Percutaneous Coronary Intervention 01/2015 - 01/2010
3	Transplantation 01/2016 - 11/2011
2	Stents 01/2018 - 02/2011
2	Injections 01/2016 - 04/2012
2	Coronary Artery Bypass (Coronary Artery Bypass Surgery) 12/2012 - 03/2009
2	Cell Transplantation 01/2012 - 07/2007
1	Punctures 01/2021
1	Bioreactors (Bioreactor) 01/2019
1	Surgical Amputation (Amputations) 04/2017
1	Nephrectomy 07/2010